Ganoderma terpenoid extracts have antimicrobial activity

Abstract

Researchers tested the antimicrobial effects of nine Ganoderma species from the Western Ghats of Maharashtra (INDIA) by
extracting their terpenoids (sesquiterpenes, diterpenes, and triterpenes). In addition, seven commonly used antibiotics were
tested for their efficacy against the sample microbes. The well assay technique was used for the tests. When compared to
conventional antibiotics, the activity of sesquiterpenoid extracts was much higher against gram-positive and gram-negative
bacteria and Candida albicans, while that of triterpenes and diterpenes was much lower. Diterpene and triterpene extract
failed to kill Candida albicans. Sesquiterpenoid extract from Ganoderma samples was the only one to exhibit antibacterial
activity among the other terpenoid extracts. Antimicrobial agents may be found in ganoderma samples; they are particularly
promising in G. lucidum, G. chalceum, and G. stipitatum.