Impact of amoxicillin sodium/clavulanate potassium and cefazolin sodium on inflammatory factor expression, discomfort, and postoperative infection in patients having orthopedic surgery

Abstract

The goal is to compare the effectiveness of two antibacterial therapies in orthopedic surgery.
Techniques: Based on the postoperative antibiotics used to prevent infection, 96 patients who had orthopedic surgery from January 2021 to
December 2022 in the Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, China, were retrospectively analyzed
and split equally into two groups. Cefazolin sodium was administered to the study group and amoxicillin sodium/clavulanate potassium was
given to the control group. A comparison was made between the two groups for the incidence of postoperative infection, pain score,
inflammatory variables, and quality of life.
Findings: Compared to the control group, the study group saw a decreased incidence of postoperative infection (p < 0.05). The visual analogue
scale (VAS) scores of the two groups were identical (p > 0.05) before to the intervention, but they substantially reduced (p < 0.05) after it, with
the former group's score being lower than the latter (p < 0.05). The levels of inflammatory factors in both groups were the same before the
intervention (p > 0.05); after the intervention, the levels substantially decreased in both groups (p < 0.05), with the study group's levels being
lower than those in the control group (p < 0.05). Following the intervention, the quality of life ratings increased for both groups (p < 0.05), with
the study group scoring higher than the control group (p < 0.05).
In summary: After orthopedic surgery, cefazolin sodium is superior than amoxicillin sodium/clavulanate potassium in avoiding infection in
orthopedic patients. To verify these results, however, this therapy approach must be expanded to more clinical settings.