Development and Validation of RP-HPLC method for Simultaneous estimation ofcombined drug in Pharmaceutical formulation

Abstract

The design, development, standardization, and quality control of medical goods are unattainable without
analytical methods. Although just a first effort was undertaken in this study, validated analytical techniques for
the determination of a single or mixed dose form have been developed. Methods for the quantitative and
qualitative analysis of nebivolol HCl and telmisartan were validated in accordance with ICH guidelines, and a
simple, rapid, sensitive, stable, and highly effective RP-HPLC method for their determination was developed.
This article includes the results of validation experiments on the solubility, wavelength, optimization of
chromatographic conditions, linearity, and system suitability of the proposed technique for quantification of
both medications. The chosen analytes were successfully quantified from the tablet formulation using the
method.Since this procedure does not cause any problems due to chemicals, etc., it would be useful to apply it
to the development of other medications.