Phytochemial investigation and evaluation of antiemetic & anthelmintic activities of Polygonum lapathifolium roots

Abstract

The goals of thisinvestigation were to identify the phytochemical components of Polygonum lapathifolium roots and to test
the efficacy of a methanolic extract of these roots as both an anti-emetic and an anthelmintic. Alkaloids, phytosterols,
triterpenes, flavonoids, and saponin were detected in the phytochemical analysis, and these compounds are responsible for
the plant's antiviral, antibacterial, antiallergic, antihypertensive, antiarrhythmic, hepatoprotective, and antiinflammatory
activitiesin animals. The extracts were tested at doses of 20, 40, 60, 80, and 100 mg/ml for their anthelmintic efficacy in an
in vitro worm model (Pheretima posthuma). At 60mg/ml, the anthelmintic activity of the root extracts was statistically
significant. The results were consistent with those obtained using piperazine citrate (10mg/ml)as a control. The chick
emesis model was used to administer copper sulfate (50mg/kg) orally to induce vomiting for the anti-emetic test. When
compared to the reference medicine metoclopramide (50mg/kg intraperitoneally), roots extract (150mg/kg orally)
demonstrated statistically significant antiemetic efficacy (89.37% Inhibition).