Antiemetic and anthelmintic Effect Polygonum lapathifolium root extract: a phytochemical study and assessment

Abstract

The goals of this research were to identify the phytochemical components of Polygonum lapathifolium
roots and to examine their anti-emetic and anthelmintic effects using a methanolic extract. Alkaloids,
phytosterols, triterpenes, flavonoids, and saponin have been identified by phytochemical analysis as having
antiviral, antibacterial, antiallergic, antihypertensive, antiarrhythmic, hepatoprotective, and antiinflammatory properties in animals. The extracts were tested at doses of 20, 40, 60, 80, and 100 mg/ml for
their anthelmintic efficacy in an in vitro worm model (Pheretima posthuma). At a concentration of 60mg/ml,
the root extracts showed considerable anthelmintic action. The results were consistent with those obtained
using piperazine citrate (10mg/ml) as a control. Copper sulphate (50mg/kg) was orally administered to
chicks in order to cause emesis as part of the anti-emetic test. When compared to the reference medicine
metoclopramide (50mg/kg intraperitoneally), roots extract (150mg/kg orally) demonstrated statistically
significant antiemetic efficacy (89.37% Inhibition).
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