The flower of Polygonum orientale Linn has antihyperglycemic properties. utilizing a mouse model of diabetes caused by steptozocin

Abstract

Polygonum orientale Linn. flower aqueous extract was tested for its hypoglycemic effects in mice with
diabetes caused by streptozotocin (STZ). Blood glucose, serum cholesterol, and liver glycogen levels were
measured after 21 days of treatment with floral extract at dosages of 100 and 200 mg/kg b.w. The floral
extract significantly decreased blood glucose level (P.0001), serum cholesterol (P.01), and increased liver
glycogen (P.0001) in Streptozotocin-induced diabetic mice. The findings support the traditional use of
Polygonum orientale Linn. flower extract as ethnomedicine for the treatment of diabetes by showing an
anti hyperglycaemic action in Streptozotocin-induced diabetic mice.