Animal models of inflammatory bowel illness and the effects of glycyrrhizic acid, ammonium salt

Abstract

Inflammation, stomach ulcers, and arthritis are just some of the conditions that licorice has been shown to help.
The demulcent glycyrrhizin found in the root is helpful for inflammatory bowel disease and colitis. Glycyrrhizic
acid, a triterpene glycoside, and 18- glycyrrhetinic acid, an aglycone of Glycyrrhizic acid, have the most wellknown and significant biological activities in licorice root, including anti-inflammatory, anti-ulcer, anti-allergic,
anti-dote, anti-oxidant, anti-viral, and anti-tumor effects. In this study, the effects of glycyrrhizinic acid (GA)
ammonium salt on inflammatory bowel disease (IBD) are assessed. The GA was tested on mice with acetic acidinduced colitis, rats with indomethacin-induced enterocolitis, and mice with ethanol-induced colitis at doses of
10, 20, and 40 mg/kg/day i.p. The gold standard for this study was the medication prednisolone. In these
experimental animal models, GA exhibited strong inhibitory action against IBD. The efficacy was similar to that
of the gold standard medication prednisolone. Evidenced by a significant decrease in lipid pero xidation measured
as MDA levels, an increase in appetite and maintenance of nutritional status, and an increase in plasma total
protein level of GA pretreated animals, the current work suggests that GA has a pharmacological capacity to
reduce oxidative stress. GA's impact comes from its treatment of the paradigm's inducer both before and after
the experiment. As a result, GA will serve both preventatively and therapeutically in the management of
inflammatory bowel disease. According to the findings of the current research, GA shows promise as an
antioxidant for warding off IBD symptoms.