Cardioprotective effect of grapeseed proanthocyanidin on doxorubicin induced myocardial injury in rats

Abstract

Grapeseed Proanthocyanidin [GSP] seeds containing a significant antioxidant and cardioprotective
capabilities were investigated against Doxorubicin induced cardiotoxicity in rats. Serum creatine
phosphokinase [CPK] elevation was seen 15 days after intraperitoneal administration of DOX [10mg kg1
/b.wt] once daily. glycogen oxidase [GOX] An enzyme called aspartate transaminase [ASP] ALT, or alanine
transaminase. Increasing levels of cardiac malondialdehyde [MDA] in response to elevated HDL cholesterol
and triglycerides are linked to decreased levels of glutathione peroxidase [Gpx], glutathione-S transferase
[GST], and glutathione reductase [GR]. Serum levels of cardiac marker enzymes normalized after 15 days
of daily oral treatment of an aqueous preparation of GSP seeds extract at the dosage of (200 mg kg b.wt).
In conclusion, the research confirms that GSP seeds have antioxidant and cardioprotective properties.