Design of novel oral films as drug delivery system

Abstract

To treat severe hypertension and acute situations such angina pectoris, researchers set out to create unique
fast-dissolving films as a medication delivery mechanism. In the current study, thin films of the
antihypertensive medication amylodipin besylate were produced utilizing polymers, plasticizers, and
super disintegrants of varying concentrations. Measurements of thickness, folding endurance, tensile
strength, and dissolving time were taken to determine the properties of the produced films. According to
the results of the research, the optimal film dissolves after only 60 seconds. This means the medicine will
dissolve rapidly, elevating its solubility and, by extension, its bioavailability.