Effect of various polymers on swelling and in vitro release oframipril in effervescent system

Abstract

Tablet can be Utilized for precise delivery of drugs and reduce the drug concentrations at sites other than
the target organ. The present study performed by preparation and evaluation of floating tablets of Ramipril
as model drug. For prolongation of gastric residence time floating effervescent tablets were formulated by
various materials like. hydroxypropyl methylcellulose (HPMC) K 4M, K 15M, K 100M and micro crystalline
cellulose and gas generating agent like sodium bicarbonate and evaluated for floating properties, swelling
characteristics and drug release studies. In vitro drug release studies were performed and drug release kinetics
evaluated using the linear regression method was found to follow both the Higuchi and the Korsemeyer
Peppas equation. The drug release mechanism was found non-fickian type in most of the formulations. The
developed floating tablets of Ramipril may be used in clinic for prolonged drug release for at least 12 h,
thereby improving the bioavailability and patient compliance.