Microsphere formulation and assessment of repaglinide

Abstract

The present investigation involves formulation and evaluation of microspheres with Repaglinide as model drug for
prolongation of drug release time. An attempt was made to prepare microspheres of Repaglinide by Quasi emulsion
solvent diffusion technique, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract
and consequently into systemic circulation. The microspheres were formulated by using various concentration of
HPMCP, Ethyl cellulose and Eudragit RSPO as a retarding agentto controlthe release rate. The prepared microspheres
were evaluated for Flow behavior, Compatibility study, Drug Entrapment Efficiency, In-vitro Dissolution, Scanning
Electron Microscopy and Particle size analysis. Among the nine formulations prepared and evaluated F1 and F9 are
found to show retarded release. In-vitro release studies indicated that, as the concentration ofretarding agent (HPMCP,
Eudragit and Ethyl cellulose) increases the formulation become more sustained.