Evaluation of a diltiazem hydrochloride buccal bioadhesive tablet formulation

Abstract

For the management of hypertension, a buccal bioadesive tablet containing diltiazem hydrochloride was
developed. As a bioadhesive polymer, a mixture of carbopol 974 and hydroxypropyl methyl cellulose K4M was
utilized. Diltiazem hydrochloride was used as a model medication, and the tablets' release was evaluated by an
in vitro dissolving test. Diltiazem hydrochloride is not broken down in the liver after oral dosing, demonstrating
a positive therapeutic effect. Different metrics, such as weight variation, tablet hardness, medication content,
bioadhesion force, and swelling index, were used to assess the tablets' performance.