Phytoconstituents evaluation by GC-MS and therapeutic efficacyof Grewiaum bellifera on streptozotocin (STZ)- induced diabetic rats

Abstract

Grewiaum bellifera is an Indian traditional medicinal plant of the Tiliaceae family. The aerial plant part
extract is much more useful in treatment like spleen damage, liver complications and cardio disorders. The
rats were treated orally with the extract of Grewiaumbellifera at 250mg and 500 mg / kg body wt.for 28days.
Biochemical parametersviz. fasting blood glucose, blood urea, serum creatinine and total cholesterol were
analyzed. Phytocontituents like Triterpene, Asarone, Diterpene, linoleic acid ester, Flavonoid compound,
Steroid compound were present in GC- MS analysis. It was also observed that fasting blood glucose showed
a significant decrease at a dose of 500mg/kg body wt. (From 280.8 ± 2.29 to 118.8 ± 3.99mg/dl) when
compared with that of standard drug glibenclamide. The results shows in this study clearly indicates that
the extract possess anti-hyperglycemic activity and may be promising for the development of
phytomedicine for diabetes mellitus.